Quan Cai

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Quan Cai

  • Email:quan_cai@fudan.edu.cn

  • Address: 220 Handan Rd., Fudan University,Yichuanxue Building, Room 512, Yangpu, Shanghai, China, 200433

  • Biography

  • Research Interests

  • Key Publications

  • Prizes and awards

  • From 2017.6      

Tenure-Track ProfessorChemistry Department, Fudan University, Shanghai, China

  • 2016.4-2017.6    

Research Fellow, with Prof. Nathanael Gray

Chemical Biology and Medicinal Chemistry

Dana-Farber Cancer Institute (DFCI), Harvard Medical School (HMS), Boston, MA, US

  • 2013.8-2016.3    

Postdoctoral Associate, with Prof. K. C. Nicolaou

Total Synthesis of Bioactive Natural Products

Rice University, Houston, TX, US

  • 2012.9-2013.7    

Postdoctoral Associate, with Prof. K. C. Nicolaou

Total Synthesis of Bioactive Natural Products

The Scripps Research Institute (TSRI), La Jolla, CA, US

  • 2007.9-2012.7    

Ph.D. in Organic Chemistry, with Prof. Shu-Li You

Asymmetric Catalysis

Shanghai Institute of Organic Chemistry (SIOC), Chinese Academy of Sciences,Shanghai, China

  • 2003.9-2007.7    

B.S. in Pharmaceutics, with Prof. Wen-Hu Duan, Prof. FengGao

East China University of Science and Technology (ECUST),Shanghai, China

  • Asymmetric Catalysis

  • Natural Product Total Synthesis

  • Medicinal Chemistry and Chemical Biology

At Fudan University

Coming soon...

Before Fudan Univeristy

15.K. C. Nicolaou*, Pengxi Chen†, Shugao Zhu†, Quan Cai†, Rohan D. Erande, Ruofan Li, Hongbao Sun, Kiran Kumar Pulukuri, Stephan Rigol, Monette Aujay, Joseph Sandoval, Julia Gavrilyuk. Streamlined Total Synthesis of Trioxacarcins and Its Application to the Design, Synthesis, and Biological Evaluation of Analogues Thereof.  Discovery of Simpler Designed and Potent Trioxacarcin Analogues.J. Am. Chem. Soc. 2017, 139, 15467. († co-first author except the corresponding author)

14.  K. C. Nicolaou*, Quan Cai, Hongbao Sun, Bo Qin, Shugao Zhu. Total Synthesis of Trioxacarcins DC-45-A1, A, D, C and C7ˊˊ-epi-C and Full Structural Assignment of Trioxacarcin C.J. Am. Chem. Soc.2016, 138, 3118.

13. K. C. Nicolaou*, Quan Cai, Bo Qin, Mette T. Peterson, Remi J. T. Mikkelsen, Philipp Heretsch. Total Synthesis of Trioxacarcin DC-45-A2. Angew. Chem. Int. Ed. 2015, 54, 3074.

12. Quan Cai, Qin Yin, Shu-Li You*. Chiral Amine Catalyzed Asymmetric Bromocyclization of Trptamine Derivatives. Asian. J. Org. Chem. 2014, 3, 408.

11. K. C. Nicolaou*, Ruocheng Yu, Lei Shi, Quan Cai, Min Lu, Phillip Heretsch. General Synthetic Approach to Functionalized Dihydrooxepines.Org. Lett. 2013, 15, 1994.

10. Quan Cai, Xiao-Wei Liang, Shou-Guo Wang, Shu-Li You*. An olefin isomerization/asymmetric Pictet–Spengler cascade via sequential catalysis of ruthenium alkylidene and chiral phosphoric acid.Org. Biomol. Chem. 2013, 11, 1602.

9.Jun-Wei Zhang, Quan Cai, Qin Gu, Xiao-Xin Shi, Shu-Li You*. Enantioselective Synthesis of Benzofurans and Benzoxazines via an Olefin Cross-Metathesis/Intramolecular Oxo-Michael Reaction.Chem. Commun. 2013, 49, 7750.

8.Quan Cai, Xiao-Wei Liang, Shou-Guo Wang, Jun-Wei Zhang, Xiao Zhang, Shu-Li You*. Ring-Closing Metathesis/Isomerization/Pictet–Spengler Cascade via Ruthenium/Chiral Phosphoric Acid Sequential Catalysis.Org. Lett. 2012, 14, 5022.

7.  Quan Cai, Chuan Liu, Xiao-Wei Liang, Shu-Li You*. Enatioselective Construction of Pyrroloindolines via Chiral Phosphoric Acid Catalyzed Cascade Michael Addition–Cyclization of Tryptamines.Org. Lett.2012, 14, 4588.

6. Quan Cai, Shu-Li You*. Organocatalyzed Enantioselective Formal [4 + 2] Cycloaddition of 2,3-Disubstituted Indole and Methyl Vinyl Ketone.Org. Lett.2012, 14, 3040.

5. Quan Cai, Chao Zheng, Jun-Wei Zhang, Shu-Li You*. Enantioselective Michael/Mannich Polycyclization Cascade of Indolyl Enones Catalyzed by Quinine-Derived Primary Amines. Angew. Chem. Int. Ed.2011, 50, 8665.

4.Jun-Wei Zhang, Quan Cai, Xiao-Xin Shi, Wei Zhang, Shu-Li You*. Enantioselective Synthesis of Tetrahydropyrano[3,4-b] Indoles Catalyzed by Chiral N-Triflyl Phosphoramide via Intramolecular Friedel-Crafts Alkylation Reaction. Synlett2011, 1239.

3. Quan Cai, Chao Zheng, Shu-Li You*. Enantioselective Intramolecular Aza-Michael Addition of Indoles Catalyzed by Chiral Phosphoric Acid. Angew. Chem. Int. Ed.2010, 49, 8666.

2. Quan Cai, Zhuo-An Zhao, Shu-Li You*. Asymmetric Construction of Polycyclic Indoles through Olefin Cross-Metathesis/ Intramolecular Friedel-Crafts Alkylation under Sequential Catalysis.Angew. Chem. Int. Ed.2009, 48, 7428.

1. Shu-Li You*, Quan Cai, Mi Zeng. Chiral Brønsted Acids Catalyzed Friedel-Crafts Alkylation Reaction.Chem. Soc. Rev. 2009, 38, 2190.

  • Thousand Youth Talents Plan of China in 2017

  • The Excellent Achievement Awards of Shanghai Graduate Students (Thesis) in 2014

  • CAS (Chinese Academy of Sciences) The Best Thesis in 2013

  • CAS (Chinese Academy of Sciences) Special Prize of President Schlorship in 2012

  • CAS (Chinese Academy of Sciences) Excellent Graduate Prize in 2012

  • The First Prize of GSK (GlaxoSmithKline) Scholarship in 2010