朱灿

欢迎来到复旦大学分子合成与识别科学中心

朱灿

  • 有机化学,青年研究员,博士生导师

  • 电子邮箱:zhucan@fudan.edu.cn

  • 办公地点:上海市杨浦区淞沪路2005号

  • 复旦大学江湾校区化学楼A5023室

  • 学习工作经历

  • 研究兴趣

  • 代表性论文及专著

  • 获奖情况

  • 小组成员

  • 2005.9-2009.7          中国科学技术大学化学系本科,获得理学学士学位

  • 2009.9-2014.7          中国科学院上海有机化学研究所研究生,获得理学博士学位

  • 2014.9-2016.8          瑞典斯德哥尔摩大学博士后

  • 2016.9-2018.6          德国明斯特大学博士后

  • 2018.7-2019.9          瑞典斯德哥尔摩大学研究员(researcher)

  • 2019.10-2020.9        瑞士巴塞尔大学博士后

  • 2020.11起                 复旦大学化学系青年研究员

  • -新型金属催化剂的设计

  • -立体化学编辑方法开发

  • -不对称催化与手性合成

  • Publications at Fudan University

    35. J. Zhang†, K. Wang†, C. Zhu*, Deracemization of Atropisomeric Biaryls Enabled by Copper Catalysis. JACS Au 2024, 4, 502−511.

    34. T. Zhang, C. Zhu*, Enzymatic Kinetic Resolution (EKR) of α-Allenols Enabled by a Commercially Available Immobilized Lipase. Synlett 2024, DOI: 10.1055/s-0042-1751525. (Invited contribution to Thieme Chemistry Journals Awardees 2023)

    33. J. Zhang, C. Zhu*, Stereochemical editing: catalytic racemization of secondary alcohols and amines. Chin. Chem. Lett. 2024, 35, 109160.

    32. D. Zhao†, B. Xu†, C. Zhu*, Migratory allylic arylation of 1,n-enols enabled by nickel catalysis. Nat. Commun. 2023, 14, 3308. Highlighted in X-MOL: https://newsletter.x-mol.com/news/857280; “化学与材料科学”; “CBG资讯”; “复旦大学新闻”

    31. C. Zhu*. Synform 2023, 08, A146–147.

    30. J. Ma†, C. Zhu†, K. Mao, W. Jiang, J. Low, D. Duan, H. Ju, D. Liu, K. Wang, Y. Zang, S. Chen, H. Zhang, Z. Qi, R. Long,* Z. Liu, L. Song, Y. Xiong*, Sustainable methane utilization technology via photocatalytic halogenation with alkali halides. Nat. Commun. 2023, 14, 1410.


  • Publications Before Fudan University

    29.C. Zhu†,* J. Liu†, B. K. Mai, F. Himo,* J.-E. Bäckvall*, Efficient Stereoselective Carbocyclization to cis-1,4-Disubstituted Heterocycles Enabled by Dual Pd/Electron Transfer Mediator (ETM) Catalysis. J. Am. Chem. Soc. 2020, 142, 5751−5759.

    28. C. Zhu†,* J. Liu†, M.-b. Li+, J.-E. Bäckvall*, Palladium-catalyzed oxidative dehydrogenative carbonylation reactions using carbon monoxide and mechanistic overviews. Chem. Soc. Rev. 2020, 49, 341−353.

    27. M.-B. Li, D. Posevins, A. Geoffroy, C. Zhu,* J.-E. Bäckvall*, Efficient Heterogeneous Palladium-Catalyzed Oxidative Cascade Reactions of Enallenols to Furan and Oxaborole Derivatives. Angew. Chem. Int. Ed. 2020, 59, 1992−1996.

    26. C. Zhu*, J.-E. Bäckvall*, An Efficient Approach to Regio- and Stereodefined Fully-Substituted Alkenylsilanes by Pd-Catalyzed Allenic C(sp3)-H Oxidation. Chem. Eur. J. 2019, 25, 11566−11573.

    25. C. Zhu†,* B. Yang†, B. K. Mai, S. Palazzotto, Y. Qiu, A. Gudmundsson, A. Ricke, F. Himo,* J.-E. Bäckvall*, Highly Selective Palladium-Catalyzed Hydroborylative Carbocyclization of Bisallenes to Seven-Membered Rings, J. Am. Chem. Soc. 2018, 140,  14324−14333.

    24. C. Zhu, J. L. Schwarz, S. Cembellín, S. Greßies, F. Glorius*, Highly Selective Manganese(I)/Lewis Acid Cocatalyzed Direct C‒H Propargylation Using Bromoallenes, Angew. Chem. Int. Ed. 2018, 57, 437−441.

    23. C. Zhu†, T. Pinkert†, S. Greßies, F. Glorius*, One-Pot C–H Formylation Enabled by Relay Catalysis of Manganese(I) and Iron(III), ACS Catal. 2018, 8, 10036−10042.

    22. B. Yang, Y. Qiu, T. Jiang, W. D. Wulff, X. Yin, C. Zhu,* J.-E. Bäckvall*, Enantioselective Pd-Catalyzed Carbonylative Carbocyclization of Enallenes via Cross-Dehydrogenative Coupling with Terminal Alkynes: Efficient Construction of α-Chirality of Ketones, Angew. Chem. Int. Ed. 2017, 56, 4535−4539.

    21. Y. Qiu, B. Yang, T. Jiang, C. Zhu, J.-E. Bäckvall*, Palladium-Catalyzed Oxidative Cascade Carbonylative Spirolactonization of Enallenols, Angew. Chem. Int. Ed. 2017, 56, 3221−3225.

    20. Y. Qiu, B. Yang, C. Zhu, J.-E. Bäckvall*, Highly Selective Olefin-Assisted  Palladium-Catalyzed Oxidative Carbocyclizationvia Remote Olefin Insertion, Chem. Sci. 2017, 8, 616−620.

    19. C. Zhu†,* B. Yang†, Y. Qiu, J.-E. Bäckvall*, Highly Selective Construction of Seven-Membered Carbocycles by Olefin-Assisted Palladium-Catalyzed Oxidative Carbocyclization–Alkoxycarbonylation of Bisallenes, Angew. Chem. Int. Ed. 2016, 55, 14405−14408.

    18. Y. Qiu, B. Yang, C. Zhu,* J.-E. Bäckvall*, Palladium-Catalyzed Oxidative Carbocyclization-Borylation of Enallenes to Cyclobutenes, Angew. Chem. Int. Ed. 2016, 55, 6520−6524.

    17. B. Yang†, C. Zhu†, Y. Qiu, J.-E. Bäckvall*, Enzyme- and Ruthenium-Catalyzed Enantioselective Transformation of α-Allenic Alcohols to 2,3-Dihydrofurans, Angew. Chem. Int. Ed. 2016, 55, 5568−5572.

    16. C. Zhu†, B. Yang†, Y. Qiu, J.-E. Bäckvall*, Olefin-Directed Palladium-Catalyzed Regio-and Stereoselective Hydroborationof Allenes, Chem. Eur. J. 2016, 22, 2939−2943.

    15. Y. Qiu, B.  Yang, C. Zhu, J. E. Bäckvall*, Highly Efficient Cascade Reaction for Selective Formation of Spirocyclobutenes from Dienallenes via Palladium-Catalyzed Oxidative Double Carbocyclization-Carbonylation-Alkynylation, J. Am. Chem. Soc. 2016, 138, 13846−13849.

    14. T. Jiang, X. Quan, C. Zhu, P. G. Andersson, J.-E. Bäckvall*, Palladium-Catalyzed Oxidative Synthesis of α-Acetoxylated Enones from Alkynes, Angew. Chem. Int. Ed. 2016, 55, 5824−5828.

    13. C. Zhu, B. Yang, J.-E. Bäckvall*, Highly Selective Cascade C-C Bond Formation via Palladium-Catalyzed Oxidative Carbonylation-Carbocyclization-Carbonylation-Alkynylation of Enallenes, J. Am. Chem. Soc. 2015, 137, 11868−11871.

    12. C. Zhu, B. Yang, T. Jiang, J.-E. Bäckvall*, Olefin-Directed Palladium-Catalyzed Regio-and Stereoselective Oxidative Arylation of Allenes, Angew. Chem. Int. Ed. 2015, 54, 9066−9069.

    11. C. Zhu, S. Ma*, Sc(OTf)3-Catalyzed Bicyclization of o-Alkynylanilines with Aldehydes: Ring-Fused 1,2-Dihydroquinolines, Angew. Chem. Int. Ed. 2014, 53, 13532−13535.

    10. C. Zhu, S. Ma*, Efficient Carbazole Synthesis via Pd/Cu-Cocatalyzed Cross-Coupling/Isomerization of 2-Allyl-3-iodoindoles and Terminalalkynes, Org. Lett. 2014, 16, 1542−1545.

    9. B. Chen†, C. Zhu†, Y. Tang, S. Ma*, Copper-mediated pyrazole synthesis from 2,3-allenoates or 2-alkynoates, amines and nitriles, Chem. Commun. 2014, 50, 7677−7679.

    8. C. Zhu, S. Ma*, Studies on Palladium-Catalyzed Efficient Synthesis of Dihydrocycloocta[b]indoles and Their Thermal Reactivities with Maleimide or Maleic Anhydride, Adv. Synth. Catal. 2014, 356, 3897−3911.

    7. W. Lin, T. Cao, W. Fan, Y. Han, J. Kuang, H. Luo, B. Miao, X. Tang, Q. Yu, W. Yuan, J. Zhang, C. Zhu, S. Ma*, Enantioselective Double Manipulation on Tetrahydroisoquinolines with Terminal Alkynes and Aldehydes under Cu(I) Catalysis, Angew. Chem. Int. Ed. 2014, 53, 277−281.

    6. C. Zhu, S. Ma*, Coupling and Cyclization of o-Iodoanilines and Propargylic Bromides via Allenes: An Efficient Entry to Indomethacin, Org. Lett. 2013, 15, 2782−2785.

    5. X. Tang, C. Zhu, T. Cao, J. Kuang, W. Lin, S. Ni, J. Zhang, S. Ma*, Cadmium iodide-mediated allenylation of alkynes with ketones, Nature Commun. 2013, 4, 2450.

    4. S. Ni, C. Zhu, J. Chen, S. Ma*, Preparation of 1-Benzyl-2-methyl-3-(ethoxycarbonyl)-4-(2-phenylethyl)-1H-pyrrole from 4-Phenyl-1,2-butadiene, Org. Synth. 2013, 90, 327−337.

    3. R. Lü, J. Ye, T. Cao, B. Chen, W. Fan, W. Lin, J. Liu, H. Luo, B. Miao, S. Ni, X. Tang, N. Wang, Y. Wang, X. Xie, Q. Yu, W. Yuan, W. Zhang, C. Zhu, S. Ma*, Bimetallic Enantioselective Approach to Axially Chiral Allenes, Org. Lett. 2013, 15, 2254−2257.

    2. C. Zhu, X. Zhang, X. Lian, S. Ma*, One-Pot Approach to Installing Eight-Membered Rings onto Indoles, Angew. Chem. Int. Ed. 2012, 51, 7817−7820.

    1. J. Cheng, X. Jiang, C. Zhu, S. Ma*, Palladium-Catalyzed Three-Component Tandem Cyclization Reaction of 2-(2,3-Allenyl)acylacetates, Organic Halides, and Amines: An Effective Protocol for the Synthesis of 4,5-Dihydro-1H-pyrrole Derivatives, Adv. Synth. Catal. 2011, 353, 1676−1682.

    †co-first authors, *corresponding author

  • Patents

    2. S. Ma*, C. Zhu, Synthesis of Dihydrocycloocta[b]indolesand Application in the Total Synthesis of Iprindole. Chinese Patent Application No.CN102675186A.

    1. S. Ma*, C. Zhu, Synthesis of Polysubstituted Indolesand Application in the Total Synthesis of Indomethacin. Chinese Patent Application No.CN103012241A.

    2023年:Thieme Chemistry Journals Award 2023

    2020年:国家海外高层次人才引进青年项目

    2020年:上海市海外高层次人才引进项目

    2016年:德国洪堡基金

    2019年:瑞典“Olle Engkvist”基金研究奖


    2021级博士研究生

    张天宇
    赵丹
    汪坤

    2022级博士研究生

    张俊
    张洁

    2022级硕士研究生

    楼丁凯

    2023级博士研究生

    郗长礼彭耀

    2023级硕士研究生


    刘烨奇


CopyRight 2017 © 复旦大学化学系分子合成与识别科学中心 版权所有