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蔡泉
有机化学，教授，博士生导师
电子邮箱(Email)：quan_cai@fudan.edu.cn
办公地点：上海市杨浦区邯郸路220号
遗传学楼513室, 200433
Address: 220 Handan Rd., Fudan University,Yichuanxue Building, Room 513, Yangpu, Shanghai, China, 200433
学习工作经历
研究兴趣
代表性论文及专著
获奖情况
小组成员
From 2017.6 复旦大学化学系教授，博士生导师
Tenure-Track Professor Chemistry Department, Fudan University, Shanghai, China
2016.4-2017.6 美国哈佛大学医学院，Dana-Farber癌症研究所， 博士后
Research Fellow, with Prof. Nathanael Gray
Chemical Biology and Medicinal Chemistry
Dana-Farber Cancer Institute (DFCI), Harvard Medical School (HMS), Boston, MA, US
2013.8-2016.3 美国Rice大学，博士后
Postdoctoral Associate, with Prof. K. C. Nicolaou
Total Synthesis of Bioactive Natural Products
Rice University, Houston, TX, US
2012.9-2013.7 美国Scripps研究所（La Jolla, CA），博士后
Postdoctoral Associate, with Prof. K. C. Nicolaou
Total Synthesis of Bioactive Natural Products
The Scripps Research Institute (TSRI), La Jolla, CA, US
2007.9-2012.7 中国科学院上海有机化学研究所，博士
Ph.D. in Organic Chemistry, with Prof. Shu-Li You
Asymmetric Catalysis
Shanghai Institute of Organic Chemistry (SIOC), Chinese Academy of Sciences,Shanghai, China
2003.9-2007.7 华东理工大学药学院，本科
B.S. in Pharmaceutics, with Prof. Wen-Hu Duan, Prof. FengGao
East China University of Science and Technology (ECUST),Shanghai, China
不对称催化反应
活性天然产物和药物分子合成
药物化学及化学生物学研究
Publications at Fudan University
29.Synthesis of Inherently Chiral Calix[4]arenes via Palladium-Catalyzed Asymmetric Intramolecular C-H Arylations. Yu-Zhen Zhang, Meng-Meng Xu, Xu-Ge Si, Jun-Li Hou, Quan Cai*. Enantioselective J. Am. Chem. Soc. 2022, 144, 22858−22864.
28.Catalytic Enantioselective Inverse-Electron-Demand Diels–Alder Reaction of 2-Pyrones and Vinylselenides. Xin-Yu You, Quan Cai*. Synlett DOI: 10.1055/a-1990-5276.
27.An Enantioselective Approach to Heteroatom-Containing Bicyclic Derivatives via Inverse-Electron-Demand Diels−Alder Reactions.Jun-Xiong He, Xu-Ge Si, Qi-Tao Lu, Qian-Wei Zhang, Quan Cai*. Chin. J. Chem.2023, 41, 21−26.
26.Progress of Catalytic Asymmetric Diels–Alder Reactions of 2-Pyrones.Meng-Meng Xu, Quan Cai*. Chin. J. Org. Chem.2022, 42, 698−713.
25.Meng-Meng Xu, Quan Cai*. A Periselective Cross-Diels–Alder Reaction. Trends in Chemistry2022, 4, 250−251.
24.Catalytic Asymmetric Inverse-Electron-Demand Diels–Alder Reactions of 2-Pyrones with Indenes: Total Syntheses of Cephanolides A and B.Yang Lu, Meng-Meng Xu, Zhi-Mao Zhang, Jun-Liang Zhang, Quan Cai*. Angew. Chem. Int. Ed. 2021, 60, 26610−26615.
23.An enantioselective ambimodal cross-Diels–Alder reaction and applications in synthesis.Meng-Meng Xu, Limin Yang, Kui Tan, Xiangyang Chen, Qi-Tao, Lu, K. N. Houk*, Quan Cai*. Nat. Catal.2021, 4, 892−900.
22. Enantioselective Synthesis of Axially Chiral Biaryls by Diels−Alder/Retro-Diels−Alder Reaction of 2‑Pyrones with Alkynes. Xu, M.-M.; You. X-Y.; Zhang, Y.-Z.; Lu, Y.; Tan, K.; Yang, L.*; Cai, Q.* J. Am. Chem. Soc. 2021, DOI: 10.1021/jacs.1c04759.
21.Asymmetric Inverse-Electron-Demand Diels-Alder Reactions of 2-Pyrones by Lewis Acid Catalysis. Si, X.-G.; Zhang, Z.-M.; Cai, Q.*Synlett 2021, 32, 947-954.
20.Enantioselective Synthesis of cis-Decalin Derivatives by the Inverse-Electron-Demand Diels–Alder Reaction of 2-Pyrones. Si, X.G.; Zhang, Z.-M.; Zheng, C.-G.; Li, Z.-T.; Cai, Q.*Angew. Chem. Int. Ed.2020, 59, 18412-18417.
19.Enantioselective Synthesis of Arene cis-Dihydrodiols from 2-Pyrones. Liang, X.-W.; Zhao, Y.; Si, X.-G.; Xu, M.-M.; Tan, J.-H.; Zhang, Z.-M.; Zheng, C.-G.; Zheng, C.; Cai, Q.*Angew. Chem. Int. Ed.2019, 58, 14562-14567.
18.The [4+2] Cycloaddition of 2-Pyrone in Total Synthesis. Cai, Q.*Chin. J. Chem.2019, 37, 946-976.
17.Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15. T. B. Faust, H. Yoon, R. P. Nowak, K. A. Donovan, Z. Li, Q. Cai, N. A. Eleuteri, T. Zhang, N. S. Gray, E. S. Fischer* Nat. Chem. Biol.2020, 16, 7-14.
16.Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models. M. C. Sliva, F. M. Ferguson, Q. Cai, K. A. Donovan, G. Nandi, D. Patnaik, T. Zhang, H.-T. Huang, D. E. Lucente, B. C. Dickerson, T. J. Mitchison, E. S. Fischer, N. S. Gray*, S. J. Haggarty* eLife 2019, e45457.
Publications before Fudan University
15.K. C. Nicolaou*, Pengxi Chen,† Shugao Zhu,† Quan Cai,† Rohan D. Erande, Ruofan Li, Hongbao Sun, Kiran Kumar Pulukuri, Stephen Rigol, Monette Aujay, Joseph Sandoval, Julia Gavrilyuk. Streamlined Total Synthesis of Trioxacarcins and Its Application to the Design, Synthesis, and Biological Evaluation of Analogues Thereof. Discovery of Simpler Designed and Potent Trioxacarcin Analogues. J. Am. Chem. Soc. 2017, 139, 15467.(co-first author except the corresponding author)
14.K. C. Nicolaou*, Quan Cai, Hongbao Sun, Bo Qin, Shugao Zhu. Total Synthesis of Trioxacarcins DC-45-A1, A, D, C and C7ˊˊ-epi-C and Full Structural Assignment of Trioxacarcin C. J. Am. Chem. Soc. 2016, 138, 3118.
13.K. C. Nicolaou*, Quan Cai, Bo Qin, Mette T. Peterson, Remi J. T. Mikkelsen, Philipp Heretsch. Total Synthesis of Trioxacarcin DC-45-A2. Angew. Chem. Int. Ed.2015, 54, 3074.
12.Quan Cai, Qin Yin, Shu-Li You*. Chiral Amine Catalyzed Asymmetric Bromocyclization of Trptamine Derivatives. Asian. J. Org. Chem.2014, 3, 408.
11.K. C. Nicolaou*, Ruocheng Yu, Lei Shi, Quan Cai, Min Lu, Phillip Heretsch. General Synthetic Approach to Functionalized Dihydrooxepines. Org. Lett. 2013, 15, 1994.
10.Quan Cai, Xiao-Wei Liang, Shou-Guo Wang, Shu-Li You*. An olefin isomerization/asymmetric Pictet–Spengler cascade via sequential catalysis of ruthenium alkylidene and chiral phosphoric acid. Org. Biomol. Chem.2013, 11, 1602.
9.Jun-Wei Zhang, Quan Cai, Qin Gu, Xiao-Xin Shi, Shu-Li You*. Enantioselective Synthesis of Benzofurans and Benzoxazines via an Olefin Cross-Metathesis/Intramolecular Oxo-Michael Reaction. Chem. Commun. 2013, 49, 7750.
8.Quan Cai, Xiao-Wei Liang, Shou-Guo Wang, Jun-Wei Zhang, Xiao Zhang, Shu-Li You*. Ring-Closing Metathesis/Isomerization/Pictet–Spengler Cascade via Ruthenium/Chiral Phosphoric Acid Sequential Catalysis. Org. Lett. 2012, 14, 5022.
7.Quan Cai, Chuan Liu, Xiao-Wei Liang, Shu-Li You*. Enantioselective Construction of Pyrroloindolines via Chiral Phosphoric Acid Catalyzed Cascade Michael Addition–Cyclization of Tryptamines. Org. Lett.2012, 14, 4588.
6.Quan Cai, Shu-Li You*. Organocatalyzed Enantioselective Formal [4 + 2] Cycloaddition of 2,3-Disubstituted Indole and Methyl Vinyl Ketone. Org. Lett.2012, 14, 3040.
5.Quan Cai, Chao Zheng, Jun-Wei Zhang, Shu-Li You*. Enantioselective Michael/Mannich Polycyclization Cascade of Indolyl Enones Catalyzed by Quinine-Derived Primary Amines. Angew. Chem. Int. Ed.2011, 50, 8665.
4.Jun-Wei Zhang, Quan Cai, Xiao-Xin Shi, Wei Zhang, Shu-Li You*. Enantioselective Synthesis of Tetrahydropyrano[3,4-b] Indoles Catalyzed by Chiral N-Triflyl Phosphoramide via Intramolecular Friedel-Crafts Alkylation Reaction. Synlett 2011, 1239.
3.Quan Cai, Chao Zheng, Shu-Li You*. Enantioselective Intramolecular Aza-Michael Addition of Indoles Catalyzed by Chiral Phosphoric Acid. Angew. Chem. Int. Ed.2010, 49, 8666.
2.Quan Cai, Zhuo-An Zhao, Shu-Li You*. Asymmetric Construction of Polycyclic Indoles through Olefin Cross-Metathesis/ Intramolecular Friedel-Crafts Alkylation under Sequential Catalysis. Angew. Chem. Int. Ed.2009, 48, 7428.
1.Shu-Li You*, Quan Cai, Mi Zeng. Chiral Brønsted Acids Catalyzed Friedel-Crafts Alkylation Reaction. Chem. Soc. Rev. 2009, 38, 2190.
2022年 国家自然科学基金委优秀青年基金
The National Science Fund for Outstanding Young Scholars in 20222020年 Thieme Chemistry Journals Award
Thieme Chemistry Journals Award in 20202017年 中组部第十三批海外高层次人才计划（青年）
Thousand Youth Talents Plan of China in 20172014年 上海市研究生优秀成果奖
The Excellent Achievement Awards of Shanghai Graduate Students in 20142013年 中国科学院百篇优秀博士学位论文奖
CAS(Chinese Academy of Sciences) The Best Thesis in 20132012年 中国科学院院长特别奖
CAS (Chinese Academy of Sciences) Special Prize of President Scholarship in 20122012年 中国科学院优秀毕业生奖
CAS (Chinese Academy of Sciences) Excellent Graduate Prize in 20122010年 葛兰素史克一等奖
The First Prize of GSK (GlaxoSmithKline) Scholarship in 2010
2020级直博生
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| 鲁杨 | 张羽真 |
2021级博士生
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| 何俊雄 | 杜远博 |
2022级直博生
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| 陆祺韬 | 冯世雄 |
2023级直博生
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| 马奕 | 蔡声瀚 |
本科生
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| 高瑞阳 |
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