欢迎来到复旦大学分子合成与识别科学中心
Email:quan_cai@fudan.edu.cn
Address: 220 Handan Rd., Fudan University,Yichuanxue Building, Room 512, Yangpu, Shanghai, China, 200433
Biography
Research Interests
Key Publications
Prizes and awards
From 2017.6
Tenure-Track ProfessorChemistry Department, Fudan University, Shanghai, China
2016.4-2017.6
Research Fellow, with Prof. Nathanael Gray
Chemical Biology and Medicinal Chemistry
Dana-Farber Cancer Institute (DFCI), Harvard Medical School (HMS), Boston, MA, US
2013.8-2016.3
Postdoctoral Associate, with Prof. K. C. Nicolaou
Total Synthesis of Bioactive Natural Products
Rice University, Houston, TX, US
2012.9-2013.7
Postdoctoral Associate, with Prof. K. C. Nicolaou
Total Synthesis of Bioactive Natural Products
The Scripps Research Institute (TSRI), La Jolla, CA, US
2007.9-2012.7
Ph.D. in Organic Chemistry, with Prof. Shu-Li You
Asymmetric Catalysis
Shanghai Institute of Organic Chemistry (SIOC), Chinese Academy of Sciences,Shanghai, China
2003.9-2007.7
B.S. in Pharmaceutics, with Prof. Wen-Hu Duan, Prof. FengGao
East China University of Science and Technology (ECUST),Shanghai, China
Asymmetric Catalysis
Natural Product Total Synthesis
Medicinal Chemistry and Chemical Biology
At Fudan University
Coming soon...
Before Fudan Univeristy
15.K. C. Nicolaou*, Pengxi Chen†, Shugao Zhu†, Quan Cai†, Rohan D. Erande, Ruofan Li, Hongbao Sun, Kiran Kumar Pulukuri, Stephan Rigol, Monette Aujay, Joseph Sandoval, Julia Gavrilyuk. Streamlined Total Synthesis of Trioxacarcins and Its Application to the Design, Synthesis, and Biological Evaluation of Analogues Thereof. Discovery of Simpler Designed and Potent Trioxacarcin Analogues.J. Am. Chem. Soc. 2017, 139, 15467. († co-first author except the corresponding author)
14. K. C. Nicolaou*, Quan Cai, Hongbao Sun, Bo Qin, Shugao Zhu. Total Synthesis of Trioxacarcins DC-45-A1, A, D, C and C7ˊˊ-epi-C and Full Structural Assignment of Trioxacarcin C.J. Am. Chem. Soc.2016, 138, 3118.
13. K. C. Nicolaou*, Quan Cai, Bo Qin, Mette T. Peterson, Remi J. T. Mikkelsen, Philipp Heretsch. Total Synthesis of Trioxacarcin DC-45-A2. Angew. Chem. Int. Ed. 2015, 54, 3074.
12. Quan Cai, Qin Yin, Shu-Li You*. Chiral Amine Catalyzed Asymmetric Bromocyclization of Trptamine Derivatives. Asian. J. Org. Chem. 2014, 3, 408.
11. K. C. Nicolaou*, Ruocheng Yu, Lei Shi, Quan Cai, Min Lu, Phillip Heretsch. General Synthetic Approach to Functionalized Dihydrooxepines.Org. Lett. 2013, 15, 1994.
10. Quan Cai, Xiao-Wei Liang, Shou-Guo Wang, Shu-Li You*. An olefin isomerization/asymmetric Pictet–Spengler cascade via sequential catalysis of ruthenium alkylidene and chiral phosphoric acid.Org. Biomol. Chem. 2013, 11, 1602.
9.Jun-Wei Zhang, Quan Cai, Qin Gu, Xiao-Xin Shi, Shu-Li You*. Enantioselective Synthesis of Benzofurans and Benzoxazines via an Olefin Cross-Metathesis/Intramolecular Oxo-Michael Reaction.Chem. Commun. 2013, 49, 7750.
8.Quan Cai, Xiao-Wei Liang, Shou-Guo Wang, Jun-Wei Zhang, Xiao Zhang, Shu-Li You*. Ring-Closing Metathesis/Isomerization/Pictet–Spengler Cascade via Ruthenium/Chiral Phosphoric Acid Sequential Catalysis.Org. Lett. 2012, 14, 5022.
7. Quan Cai, Chuan Liu, Xiao-Wei Liang, Shu-Li You*. Enatioselective Construction of Pyrroloindolines via Chiral Phosphoric Acid Catalyzed Cascade Michael Addition–Cyclization of Tryptamines.Org. Lett.2012, 14, 4588.
6. Quan Cai, Shu-Li You*. Organocatalyzed Enantioselective Formal [4 + 2] Cycloaddition of 2,3-Disubstituted Indole and Methyl Vinyl Ketone.Org. Lett.2012, 14, 3040.
5. Quan Cai, Chao Zheng, Jun-Wei Zhang, Shu-Li You*. Enantioselective Michael/Mannich Polycyclization Cascade of Indolyl Enones Catalyzed by Quinine-Derived Primary Amines. Angew. Chem. Int. Ed.2011, 50, 8665.
4.Jun-Wei Zhang, Quan Cai, Xiao-Xin Shi, Wei Zhang, Shu-Li You*. Enantioselective Synthesis of Tetrahydropyrano[3,4-b] Indoles Catalyzed by Chiral N-Triflyl Phosphoramide via Intramolecular Friedel-Crafts Alkylation Reaction. Synlett2011, 1239.
3. Quan Cai, Chao Zheng, Shu-Li You*. Enantioselective Intramolecular Aza-Michael Addition of Indoles Catalyzed by Chiral Phosphoric Acid. Angew. Chem. Int. Ed.2010, 49, 8666.
2. Quan Cai, Zhuo-An Zhao, Shu-Li You*. Asymmetric Construction of Polycyclic Indoles through Olefin Cross-Metathesis/ Intramolecular Friedel-Crafts Alkylation under Sequential Catalysis.Angew. Chem. Int. Ed.2009, 48, 7428.
1. Shu-Li You*, Quan Cai, Mi Zeng. Chiral Brønsted Acids Catalyzed Friedel-Crafts Alkylation Reaction.Chem. Soc. Rev. 2009, 38, 2190.
Thousand Youth Talents Plan of China in 2017
The Excellent Achievement Awards of Shanghai Graduate Students (Thesis) in 2014
CAS (Chinese Academy of Sciences) The Best Thesis in 2013
CAS (Chinese Academy of Sciences) Special Prize of President Schlorship in 2012
CAS (Chinese Academy of Sciences) Excellent Graduate Prize in 2012
The First Prize of GSK (GlaxoSmithKline) Scholarship in 2010